neutrophil elastase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9964	BOS-318		Others
	BOS-318 is a Furin inhibitor with slowly dissociating, highly selective, and cell-pemeable characteristcs.		Others
T79397	Neutrophil elastase inhibitor 4
	Neutrophil elastase inhibitor 4 (compound 4f) is a competitive inhibitor of human neutrophil elastase (HNE) with IC50 of 42.30 nM and Ki of 8.04 nM. It prompts apoptosis in T47D cells and inhibits the proliferation of T4...
T13389	ZD-0892		PI3K
	ZD-0892 is a selective and poten neutrophil elastaset inhibitor(human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 and 200 nM, respectively).		PI3K
T3107	Alvelestat	AZD9668,Avelestat	Others , Serine Protease
	Alvelestat (AZD9668) is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.		Others , Serine Protease
T6986	Sivelestat	ONO5046,EI546,LY544349	Others , SARS-CoV , Serine Protease
	Sivelestat (ONO5046) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM.		Others , SARS-CoV , Serine Protease
T12613L	BAY-85-8501		Serine Protease
	BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE; IC50 of 65 pM)		Serine Protease
T8563	2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one		Serine Protease
	2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one is an human neutrophil elastase inhibitor.		Serine Protease
T68099	Midesteine	MR-889	Others
	Midesteine (MR-889) is a small molecule neutrophil elastase inhibitor used in the treatment of bronchitis, asthma and chronic lung disease.		Others
T8602	2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-ONE		Serine Protease
	2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-ONE targets the Neutrophil elastase (human).		Serine Protease
T10473	BAY-678		Others
	BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).		Others
T25131	AZD8309	AZD 8309,AZD-8309	Glutathione Peroxidase , CXCR
	AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas and lung, and decreases trypsin and elastase activity in the...		Glutathione Peroxidase , CXCR
T20762	Sivelestat sodium tetrahydrate	ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046	Serine Protease
	Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for...		Serine Protease
T15285	FK706		Serine Protease
	FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively)...		Serine Protease
T10254	AE-3763		Serine Protease
	AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).		Serine Protease
T17288	ZD8321		Serine Protease
	ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).		Serine Protease
T31877	Freselestat	ONO-PO 736,ONO-6818,ONO 6818,ONO6818
	Freselestat (ONO-6818) is a potent neutrophil elastase inhibitor that significantly reduces the production of interleukin 8 and C5B-9. Freselestat reduces inflammatory mediators during simulated cardiopulmonary bypass.
T25520	ICI 200355	ICI-200,355,ICI 200,355,ICI-200355,ICI200,355,ICI200355
	ICI 200355 is an inhibitor of human neutrophil elastase.
T25781	MDL 101146	MDL-101146,MD 101,146,MDL101146,MDL 101,146,MDL-101,146
	MDL 101146 is an orally active neutrophil elastase inhibitor.
T25521	Ici 200880	Ici 200,880,Ici-200880,Ici200,880,Ic-200,880,Ici200880
	Ici 200880 is a human neutrophil elastase synthetic peptide inhibitor.
T11525	GW311616		Others
	GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).		Others
T25518	Ici 186756	Ici186756,Ici--186756
	Ici 186756 is a novel, effective, and selective inhibitor of human neutrophil elastase.
T25784L	MDL-101146, (S)-	MDL101146, (S)-
	MDL-101146, (S)- is an effective orally active inhibitor of human neutrophil elastase.
T25782	MDL 27324	MDL-27,324,MDL-27324,MDL27,324,MDL 27,324,MDL27324
	MDL 27324 is an inhibitor of human neutrophil elastase.
T69790	GW-475151
	GW-475151 inhibits human neutrophil elastase (HNE).
T25784	MDL-101146, (R)-	MDL101146, (R)-
	MDL-101146, (R)- is an effective orally active inhibitor of human neutrophil elastase.
T27747	KRP-109	KRP 109,KRP109
	KRP-109, a neutrophil elastase (NE) inhibitor, acts by decreasing expression of TGF-ß Signal Related Genes.
T3107L	Alvelestat tosylate
	Alvelestat can inhibit neutrophil elastase (NE), which acts an important role in NET formation.
T28244	Ono EI-601	OnoEI601,Ono-EI 601,Ono-EI-601
	Ono EI-601 is the main metabolite of ONO-5046, the human neutrophil elastase inhibitor .
T41043	Lonodelestat	POL6014
	Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE).
T11525L	GW311616 hydrochloride	GW311616A	Others
	GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).		Others
T11865	Lodelaben	SC-39026,Declaben	Others
	Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.		Others
T68240	AZD-9819
	AZD-9819 is an inhibitor of human neutrophil elastase for potential treatment of chronic obstructive pulmonary disease (COPD).
T19202	BAY-678 racemate		Others
	BAY-678 racemate is a racemate of BAY-678. BAY-678 is an orally bioavailable, selective and cell-permeable inhibitor of human neutrophil elastase (HNE; IC50: 20 nM).		Others
T21414	Sivelestat sodium	ONO 5046,LY-544349,Sivelestat sodium salt,ONO-5046,ONO5046,LY544349,LY 544349
	Sivelestat, an inhibitor of human neutrophil elastase, is used in the treatment of acute respiratory failure. Preliminary studies show Sivelestat may improve neuropathic pain.
T80553	MeOSuc-AAPA-CMK
	MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase (HNE) [1].
T12613	(R)-BAY-85-8501		Others
	(R)-BAY-85-8501 is the less active enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent Human Neutrophil Elastase (HNE)inhibitor(IC50 of 65 pM).		Others
T38363	MeOSuc-AAPV-pNA
	Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neut...
T73657	Tiprelestat
	Tiprelestat, a potent inhibitor of human neutrophil elastase, exhibits antimicrobial and anti-inflammatory properties. It is utilized in the study of inflammation and immune diseases [1].
T72111	Ala-Ala-Pro-Val-chloromethylketone	AAPV-CMK
	Ala-Ala-Pro-Val-chloromethylketone serves as an irreversible inhibitor of human neutrophil elastase (NE), utilized in researching chronic inflammatory airway diseases.
T62846	Freselestat quarterhydrate
	Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent, orally active inhibitor of neutrophil elastase (Ki: 12.2 nM). quarterhydrate is more than 100-fold less active than other proteases such as trypsin, prote...
T10473L	BAY-677		Others
	BAY-677, serving as an inactive control for BAY-678, is distinguished by BAY-678's capabilities as an orally bioavailable, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), showcasing a high pot...		Others
T76248	Tutuilamide A
	Tutuilamide A, a potent inhibitor of porcine pancreatic elastase (PPE) with an IC50 of 1.2 nM, also effectively inhibits human neutrophil elastase (HNE; IC50=0.73 nM) and kallikrein 7 (KLK7; IC50=5.0 nM) [1].
T36339	Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp
	Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human neutrophil elastase (kcat/Km = 531 mM-1s-1). Enzymatic peptide hydrolysis disrupts the Abz:EDDnp donor-acceptor pair al...
T76216	Lonodelestat TFA
	Lonodelestat TFA (POL6014 TFA) is a potent, selective peptide inhibitor of human neutrophil elastase (hNE), demonstrating oral activity. It holds promise for cystic fibrosis (CF) research [1] [2] [3].
T79496	Cathepsin C-IN-6
	Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastase activation. This compound demonstrates potential efficacy in tr...
T21989	SSR 69071
	SSR69071 is a potent, orally active, and selective inhibitor of neutrophil elastase. SSR69071 displays a higher affinity for human elastase (Ki =0.0168 nM) than for rat (Ki =3 nM), mouse (Ki =1.8 nM), and rabbit (Ki = 58...
T73532	JO146
	JO146 is a protease inhibitor for Chlamydia trachomatis high temperature requirement A (CtHtrA) and human neutrophil elastase (HNE), with IC50 values of 21.86 μM for CtHtrA and 1.15 μM for HNE, respectively. It is effect...
T80254	Elafin(human)
	Elafin, also referred to as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a protein that serves as a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3, particular...

Compounds

BOS-318

T9964

Synonym:

Target: Others

Neutrophil elastase inhibitor 4

Synonym: AZD9668,Avelestat

Target: Others, Serine Protease

Sivelestat

T6986

Synonym: ONO5046,EI546,LY544349

Target: Others, SARS-CoV, Serine Protease

BAY-85-8501

T12613L

Synonym:

Target: Serine Protease

2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one

T8563

Synonym:

Target: Serine Protease

2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE

T8602

Synonym:

Target: Serine Protease

Synonym: AZD 8309,AZD-8309

Target: Glutathione Peroxidase, CXCR

Sivelestat sodium tetrahydrate

T20762

Synonym: ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046

Target: Serine Protease

FK706

T15285

Synonym:

Target: Serine Protease

AE-3763

T10254

Synonym:

Target: Serine Protease

ZD8321

T17288

Synonym:

Target: Serine Protease

Freselestat

T31877

Synonym: ONO-PO 736,ONO-6818,ONO 6818,ONO6818

Target:

ICI 200355

T25520

Synonym: ICI-200,355,ICI 200,355,ICI-200355,ICI200,355,ICI200355

Target:

MDL 101146

T25781

Synonym: MDL-101146,MD 101,146,MDL101146,MDL 101,146,MDL-101,146

Target:

Ici 200880

T25521

Synonym: Ici 200,880,Ici-200880,Ici200,880,Ic-200,880,Ici200880

Synonym: Ici186756,Ici--186756

Target:

MDL-101146, (S)-

T25784L

Synonym: MDL101146, (S)-

Target:

MDL 27324

T25782

Synonym: MDL-27,324,MDL-27324,MDL27,324,MDL 27,324,MDL27324

Synonym: MDL101146, (R)-

Target:

KRP-109

T27747

Synonym: KRP 109,KRP109

Synonym: OnoEI601,Ono-EI 601,Ono-EI-601

GW311616 hydrochloride

Synonym: SC-39026,Declaben

Synonym: ONO 5046,LY-544349,Sivelestat sodium salt,ONO-5046,ONO5046,LY544349,LY 544349

Ala-Ala-Pro-Val-chloromethylketone

T72111

Synonym: AAPV-CMK

Target:

Freselestat quarterhydrate

Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp

Cat No.	Product Name	Synonyms	Targets
TJS0314	5,7-Dihydroxy-4-methylcoumarin	Methyl-2H-Chromen-2-One,4-Methyllimetol,4-Methyl-5,7-Dihydroxycoumarin	Others , Antibacterial , Antifungal
	5,7-Dihydroxy-4-methylcoumarin (Methyl-2H-Chromen-2-One) inhibits human neutrophil oxidative metabolism and elastase activity. 5,7-Dihydroxy-4-methylcoumarin has in vitro platelet antiaggregatory property. 5,7-Dihydroxy-...		Others , Antibacterial , Antifungal
TN4584	Morolic acid		IL Receptor , COX , HIV Protease
	Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediat...		IL Receptor , COX , HIV Protease

Cat No.	Product Name	Species	Expression System
TMPH-01773	ELANE Protein, Human, Recombinant (GST)	Human	E. coli
	Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Capable of killing E.coli but not S.aureus in vitro; digests outer membrane pro...
TMPY-00672	Azurocidin/CAP37 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil...
TMPY-01909	Elafin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Elafin, also known as Elastase-specific inhibitor, Peptidase inhibitor 3, Protease inhibitor WAP3, Skin-derived antileukoproteinase, WAP four-disulfide core domain protein 14, PI3, WAP3 and WFDC14, is a secreted protein ...

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Recombinant Proteins

Compounds

Natural Products

Recombinant Proteins